Isoindol-1-one Analogues of 4-(2‘-methoxyphenyl)-1-[2‘-[ N -(2‘‘-pyridyl)- p -iodobenzamido]ethyl]piperazine ( p -MPPI) as 5-HT 1A Receptor Ligands
✍ Scribed by Zhuang, Zhi-Ping; Kung, Mei-Ping; Mu, ; Kung, Hank F.
- Book ID
- 126286186
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 184 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
The in vivo regional distribution and pharmacological profile of a novel iodinated phenylpiperazine derivative, [12311p-MPPI (4-(2'-methoxy-)phenyl-l-[2'-(N-2"pyridinyl)-p-iodobenzamido-Iethyl-piperazine), in the rat brain were evaluated for use as a potential in vivo imaging agent for 5-HTlA recept
A series of 2-[~-(4-arylpiperazin-1-yl)aikyl]-1,3-dioxoperhydroimidazo[ 1,5-a]pyridine derivatives was prepared and evaluated for affinity at 5-HT~A and ct I receptors. The most promising analogue Ira bound at 5-HT~A sites with nanomolar affinity (/~.=31.7) and high selectivity over ~, D2 and 5-HT2A