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Natural history of Japanese children with chronic hepatitis B: Seroconversion from HBeAg to anti-HBe

✍ Scribed by AKIHIKO KIMURA; MAKADO MATSUYUKI; KEN YUGE; EIICHIRO ONO; NORIKAZU KURIYA; HIROHISA KATO


Book ID
118711922
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
277 KB
Volume
35
Category
Article
ISSN
1328-8067

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Hepatitis B virus DNA clones were propagated from sera of six patients with chronic hepatitis B who seroconverted from HBeAg to antibody to HBeAg either spontaneously or after administration of Q- interferon. Defects in the precore region blocking synthesis and secretion of HBeAg were detected in al