Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy

✍ Scribed by Kiyoshi Takeda; Yoshihiro Akahane; Hiroshi Suzuki; Hiroaki Okamoto; Fumio Tsuda; Yuzo Miyakawa; Makoto Mayumi

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 562 KB
• Volume: 12
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.1840120606

✦ Synopsis

Hepatitis B virus DNA clones were propagated from sera of six patients with chronic hepatitis B who seroconverted from HBeAg to antibody to HBeAg either spontaneously or after administration of Q- interferon. Defects in the precore region blocking synthesis and secretion of HBeAg were detected in all 46 hepatitis B virus DNA clones from three patients