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Native Chemical Ligation at Valine

โœ Scribed by Christian Haase; Heike Rohde; Oliver Seitz


Book ID
101563796
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
313 KB
Volume
47
Category
Article
ISSN
0044-8249

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C-Terminal peptide thioesters are shown to react efficiently with peptide fragments containing an Nterminal selenocysteine to give selenoproteins. In analogy to the native chemical ligation of thioesters and peptides containing N-terminal cysteines, the selenol presumably attacks the thioester nucle