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Dual Native Chemical Ligation at Lysine

โœ Scribed by Yang, Renliang; Pasunooti, Kalyan Kumar; Li, Fupeng; Liu, Xue-Wei; Liu, Chuan-Fa


Book ID
125505149
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
194 KB
Volume
131
Category
Article
ISSN
0002-7863

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C-Terminal peptide thioesters are shown to react efficiently with peptide fragments containing an Nterminal selenocysteine to give selenoproteins. In analogy to the native chemical ligation of thioesters and peptides containing N-terminal cysteines, the selenol presumably attacks the thioester nucle