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Native Chemical Ligation at Phenylalanine

โœ Scribed by Crich, David; Banerjee, Abhisek


Book ID
111861358
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
60 KB
Volume
129
Category
Article
ISSN
0002-7863

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C-Terminal peptide thioesters are shown to react efficiently with peptide fragments containing an Nterminal selenocysteine to give selenoproteins. In analogy to the native chemical ligation of thioesters and peptides containing N-terminal cysteines, the selenol presumably attacks the thioester nucle