𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Naphthalimido derivatives as antifolate thymidylate synthase inhibitors

✍ Scribed by MP Costi; D Tondi; M Rinaldi; D Barlocco; G Cignarella; DV Santi; C Musiu; I Pudu; G Vacca; P La Colla

Book ID
108422145
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
398 KB
Volume
31
Category
Article
ISSN
0223-5234

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

The synthesis of novel nonclassical reve
The synthesis of novel nonclassical reversed bridge quinazoline antifolates as inhibitors of thymidylate synthase
✍ Aleem Gangjee; Mohit KotharΓ©; Roy L. Kisliuk πŸ“‚ Article πŸ“… 2000 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 427 KB

## Abstract 2‐Amino‐6‐methyl‐5‐(pyridin‐4‐ylsulfanyl)‐3__H__‐quinazolin‐4‐one (**3**, AG337) a lipophilic thymidylate synthase inhibitor, is currently in clinical trials as an antitumor agent. On the basis of the crystal structure of **3** and the classical inhibitor 10‐propargyl‐5,8‐dideazafolic a