ChemInform Abstract: Naphthalimido Derivatives as Antifolate Thymidylate Synthase Inhibitors.
โ Scribed by M. P. COSTI; D. TONDI; M. RINALDI; D. BARLOCCO; G. CIGNARELLA; D. V. SANTI; C. MUSIU; I. PUDU; G. VACCA; P. LA COLLA
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 30 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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## Abstract 2โAminoโ6โmethylโ5โ(pyridinโ4โylsulfanyl)โ3__H__โquinazolinโ4โone (**3**, AG337) a lipophilic thymidylate synthase inhibitor, is currently in clinical trials as an antitumor agent. On the basis of the crystal structure of **3** and the classical inhibitor 10โpropargylโ5,8โdideazafolic a
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