Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors
โ Scribed by Marsham, Peter R.; Wardleworth, J. Michael; Boyle, F. Thomas; Hennequin, Laurent F.; Kimbell, Rosemary; Brown, Melody; Jackman, Ann L.
- Book ID
- 120591498
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 249 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
## Abstract 2โAminoโ6โmethylโ5โ(pyridinโ4โylsulfanyl)โ3__H__โquinazolinโ4โone (**3**, AG337) a lipophilic thymidylate synthase inhibitor, is currently in clinical trials as an antitumor agent. On the basis of the crystal structure of **3** and the classical inhibitor 10โpropargylโ5,8โdideazafolic a
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โFull Textโ option. The original article is trackable v