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N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors

✍ Scribed by Aleem Gangjee; Sonali Kurup; Michael A. Ihnat; Jessica E. Thorpe; Bryan Disch


Book ID
113495623
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
391 KB
Volume
20
Category
Article
ISSN
0968-0896

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## Abstract Receptor tyrosine kinases such as VEGFR2 (vascular endothelial growth factor receptor 2, KDR) or EGFR (epidermal growth factor receptor) play crucial roles in a variety of diseases, such as cancer. Recently, some pyrrolopyrimidines were shown to be potent EGFR inhibitors. Therefore, new