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ChemInform Abstract: Novel 3-Alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 Receptor Tyrosine Kinase Inhibitors.

✍ Scribed by Richard Ducray; Peter Ballard; Bernard C. Barlaam; Mark D. Hickinson; Jason G. Kettle; Donald J. Ogilvie; Catherine B. Trigwell


Publisher
John Wiley and Sons
Year
2008
Weight
16 KB
Volume
39
Category
Article
ISSN
0931-7597

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## Abstract Receptor tyrosine kinases such as VEGFR2 (vascular endothelial growth factor receptor 2, KDR) or EGFR (epidermal growth factor receptor) play crucial roles in a variety of diseases, such as cancer. Recently, some pyrrolopyrimidines were shown to be potent EGFR inhibitors. Therefore, new