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N-Substituted (β-d-galactopyranosylmethyl)amines as reversible inhibitors of β-d-galactosidase

✍ Scribed by James N. BeMiller; Regina J. Gilson; Robert W. Myers; Marcelo M. Santoro; Madhav P. Yadav

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
529 KB
Volume
250
Category
Article
ISSN
0008-6215

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✦ Synopsis

Through the use of a series of N-substituted (B-o-galactopyranosylmethyl)amines @Gal-CH,NHR) and the corresponding N-substituted C-(P-u-galactopyranosyl)formamides @Gal-CO-NHR), it has been determined that the inhibitor binding constant is influenced more by the pK, of the amine group than by the nature of the hydrophobic group. It is concluded that the compounds that are the best inhibitors are those which allow proton donation in the active site to form an ion

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