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N-Substituted derivatives of 4-piperidinyl benzilate: Affinities for brain muscarinic acetylcholine receptors

✍ Scribed by Shanaz M. Tejani-Butt; Gary R. Luthin; Barry B. Wolfe; David J. Brunswick


Book ID
118344570
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
377 KB
Volume
47
Category
Article
ISSN
0024-3205

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A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M1 agonists. By control of the physicochemical characteristics of the series, particularly the lipophilicity, compounds with good metabolic stability and