Discovery of Novel N -Substituted Oxindoles as Selective M 1 and M 4 Muscarinic Acetylcholine Receptors Partial Agonists
β Scribed by Sumiyoshi, Takaaki; Enomoto, Takeshi; Takai, Kentaro; Takahashi, Yoko; Konishi, Yasuko; Uruno, Yoshiharu; Tojo, Kengo; Suwa, Atsushi; Matsuda, Harumi; Nakako, Tomokazu; Sakai, Mutsuko; Kitamura, Atsushi; Uematsu, Yasuaki; Kiyoshi, Akihiko
- Book ID
- 120391384
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 744 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1948-5875
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π SIMILAR VOLUMES
A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M1 agonists. By control of the physicochemical characteristics of the series, particularly the lipophilicity, compounds with good metabolic stability and
## Abstract magnified image Furanyl and oxazolyl Nβsubstituted imidazoline salts were prepared by reacting furanyl and oxazolyl esters with ethylenediamine and trimethyl aluminum, followed by the addition of methyl iodide or hydrogen chloride. The piperidinium salts were prepared by treating furan