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N-Oxidation of Epothilone A–C and O-Acyl Rearrangement to C-19- and C-21-Substituted Epothilones

✍ Scribed by Gerhard Höfle; Nicole Glaser; Michael Kiffe; Hans-Jürgen Hecht; Florenz Sasse; Hans Reichenbach

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
115 KB
Volume
38
Category
Article
ISSN
0044-8249

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N-Oxidation von Epothilon A–C und O-Acyl
N-Oxidation von Epothilon A–C und O-Acylumlagerung zu C-19- und C-21-substituierten Epothilonen
✍ Gerhard Höfle; Nicole Glaser; Michael Kiffe; Hans-Jürgen Hecht; Florenz Sasse; H 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 115 KB

Professor Wolfgang Steglich zum 65. Geburtstag gewidmet Die Epothilone A (1 a) und B (1 b) bilden die Stammverbindungen einer neuen Familie cytotoxischer und antifungischer Makrolide aus dem Myxobakterium Sorangium cellulosum. [1] Ihre Wirkung auf eukaryontische Zellen beruht nach Bollag et al. [2]

ChemInform Abstract: Synthesis Toward Ep
ChemInform Abstract: Synthesis Toward Epothilone A: Coupling Reaction Between the Sulfone of C1—C10 and the Allylic Bromide of C11—C21.
✍ Hyo Won Lee; Yong Deog Hong; Ihl-Young Choi Lee 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 2 views

Synthesis Toward Epothilone A: Coupling Reaction Between the Sulfone of C 1 -C 10 and the Allylic Bromide of C 11 -C 21 . -The synthesis of macrolide (XII), a precursor of epothilone A, involving the coupling between allylic bromide (IX) and sulfone (X) as the key step is reported. -