ChemInform Abstract: Synthesis Toward Epothilone A: Coupling Reaction Between the Sulfone of C1—C10 and the Allylic Bromide of C11—C21.

✍ Scribed by Hyo Won Lee; Yong Deog Hong; Ihl-Young Choi Lee

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 34 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199941263

✦ Synopsis

Synthesis Toward Epothilone A: Coupling Reaction Between the Sulfone of C 1 -C 10 and the Allylic Bromide of C 11 -C 21 .

-The synthesis of macrolide (XII), a precursor of epothilone A, involving the coupling between allylic bromide (IX) and sulfone (X) as the key step is reported. -