N-Methylation of amides, lactams, and ureas
โ Scribed by Auerbach, Joseph.; Zamore, McFord.; Weinreb, Steven M.
- Book ID
- 121401152
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 252 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
A one pot selective mend N-alkylation of primary amides, thioamides, carbamates and ureas has been developed using aromatic and aliphatic aldehydes as alkylating agents and trifluoroacetic acid / triethylsilane as reagents. Application to an efficient synthesis of a primary amine from the correspond
A new procedure for protecting the amide, lactam, urea, and carbamate NH group with a triphenylmethyl (Tr) group is described. The utility of this method is illustrated with molecules that contain other functional groups. A mild deprotection using trifluoroacetic acid makes this a useful method for