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A simple synthetic protocol for the protection of amides, lactams, ureas, and carbamates

โœ Scribed by Dandu R Reddy; Mohamed A Iqbal; Robert L Hudkins; Patricia A Messina-McLaughlin; John P Mallamo


Book ID
104252185
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
179 KB
Volume
43
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


A new procedure for protecting the amide, lactam, urea, and carbamate NH group with a triphenylmethyl (Tr) group is described. The utility of this method is illustrated with molecules that contain other functional groups. A mild deprotection using trifluoroacetic acid makes this a useful method for attaching amide groups on resin for combinatorial synthesis.


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