N-Heterocyclic Carbene-Palladium Complex Catalyzed Oxidative Carbonylation of Amines to Ureas
✍ Scribed by Shu-Zhan Zheng; Xin-Gao Peng; Jian-Ming Liu; Wei Sun; Chun-Gu Xia
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 73 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0256-7660
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## Abstract A highly efficient oxidative carbonylation reaction of amines to ureas was developed making use of carbene–palladium complexes in the absence of any promoter. Both aliphatic amines and aromatic amines were transformed in good to excellent yields to the expected ureas.
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## Abstract The synthesis of ureas from amines has traditionally been accomplished with stoichiometric reactions of phosgene or its derivatives, which are associated with environmental and waste disposal issues. Because of the prevalence of urea moieties in molecules of interest for several applica