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N-(4-Hydroxyphenyl)retinamide (4-HPR) Induces Leukemia Cell Death via Generation of Reactive Oxygen Species

✍ Scribed by Hiroaki Goto; Hiroyuki Takahashi; Hisaki Fujii; Koichiro Ikuta; Shumpei Yokota


Book ID
105675953
Publisher
Carden Jennings Publishing
Year
2003
Tongue
English
Weight
168 KB
Volume
78
Category
Article
ISSN
0925-5710

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## Abstract To explore the mechanisms underlying the pro‐apoptotic effects of the synthetic retinoid N‐4‐(hydroxyphenyl)retinamide (4‐HPR) on LNCaP human prostate cancer cells, we used the differential display–polymerase chain reaction (DD‐PCR) technique to identify 4‐HPR–responsive genes. RNA extr