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Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-Hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells

✍ Scribed by Suzuki, Seigo; Higuchi, Masahiro; Proske, Rita J; Oridate, Nobuhiko; Hong, Waun K; Lotan, Reuben

Book ID: 110062410
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 343 KB
Volume: 18
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1203024

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## Abstract __N__‐(4‐hydroxyphenyl)retinamide (4HPR, fenretinide), a retinoic acid (RA) derivative and a potential cancer preventive agent, is known to exert its chemotherapeutic effects in cancer cells through induction of apoptosis. Earlier work from our laboratory has shown that relatively low c