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N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1

✍ Scribed by Curt D. Haffner; Stephen A. Thomson; Yu Guo; Lee T. Schaller; Sharon Boggs; Scott Dickerson; Jeff Gobel; Dan Gillie; J. Patrick Condreay

Book ID: 104004963
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 414 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.09.132

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✦ Synopsis

We report the synthesis and in vitro activity of a series of novel N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs. These analogs showed potent inhibitory activity against Kv1.3. Several compounds, including compound 8b, showed similar potency to the known Kv1.3 inhibitor PAP-1 when tested under the IonWorks patch clamp assay conditions.

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