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N -(2-Hydroxypropyl)methacrylamide Copolymer−6-(3-Aminopropyl)-ellipticine Conjugates. Synthesis, in Vitro, and Preliminary in Vivo Evaluation

✍ Scribed by Searle, F.; Gac-Breton, S.; Keane, R.; Dimitrijevic, S.; Brocchini, S.; Sausville, E. A.; Duncan, R.


Book ID
126791383
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
119 KB
Volume
12
Category
Article
ISSN
1043-1802

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✍ Jun H. Lee; Gauri Sabnis; Anjan Nan 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB

## Abstract Trastuzumab (TRZ) is a humanized monoclonal antibody that targets the extracellular domain of the human epidermal growth factor receptor type 2 (Her2). Semitelechelic (ST) poly[__N__‐(2‐hydroxypropyl)methacrylamide]–TRZ conjugates are successfully synthesized and evaluated as a potentia