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Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes

✍ Scribed by Akiko Asada; Naoyuki Yamamoto; Masaki Gohda; Taro Saito; Nobuhiro Hayashi; Shin-ichi Hisanaga


Book ID
111180976
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
731 KB
Volume
106
Category
Article
ISSN
0022-3042

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The ubiquitously expressed cyclinzone, which may restrict cdk5 activation to the postmidependent kinase 5 (cdk5) is essential for brain develtotic neural cells in the developing brain. The expresopment. Bioactivation of cdk5 in the brain requires sion levels of p35 and p39 mRNAs in the marginal the