Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

✍ Scribed by Zheng, Min ;Leung, Conrad L. ;Liem, Ronald K. H.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 944 KB
• Volume: 35
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199805)35:2<141::aid-neu2>3.0.co;2-4

✦ Synopsis

The ubiquitously expressed cyclinzone, which may restrict cdk5 activation to the postmidependent kinase 5 (cdk5) is essential for brain develtotic neural cells in the developing brain. The expresopment. Bioactivation of cdk5 in the brain requires sion levels of p35 and p39 mRNAs in the marginal the presence of one of two related regulatory subunits, zone increase by E15 and E17, paralleling the neuro-p35 and p39. Since either protein alone can activate genetic timetable. One exception is in the rostral fore-cdk5, the significance of their coexistence as cdk5 kibrain, where p35 mRNA expression levels are high, nase activators is unclear. To determine whether the suggesting that p35 may be the major activator for two activators are expressed in different cells through-cdk5 during telencephalic morphogenesis. A signifiout the nervous system and during development, we cant level of p35 mRNA is present in the myotome at compared the tissue distributions of cdk5, p35, and E12 and p35 expression persists in the premuscle mass p39 mRNAs in the rat using in situ hybridization.

and mature musculature at later stages, suggesting In the adult rat, expression levels of p35 mRNA are that p35 may also activate cdk5 during myogenesis. generally higher in the brain than in the spinal cord,