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Myostatin maps to porcine chromosome 15 by linkage and physical analyses

✍ Scribed by T. S. Sonstegard; G. A. Rohrer; T. P. L. Smith

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
74 KB
Volume
29
Category
Article
ISSN
0268-9146

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✦ Synopsis

Myostatin belongs to the transforming growth factor‐β superfamily, and is expressed specifically in developing and mature skeletal muscle. Myostatin appears to act as a negative regulator of muscle development, since mice with targeted disruption of this gene display a large increase in muscle mass. In this study, the porcine myostatin gene was mapped to chromosome 15q2Β·3 by fluorescence in situ hybridization. Myostatin was also positioned within the chromosome 15 linkage group using both a polymorphism located in the second intron and an associated microsatellite. The development of highly polymorphic markers associated with myostatin will support population studies to identify alleles of this gene that affects muscle mass and/or fat deposition in swine.

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