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Conservation of the syntenies between porcine chromosome 7 and human chromosomes 6, 14 and 15 demonstrated by radiation hybrid mapping and linkage analysis

โœ Scribed by M. Tanaka; T. Matsumoto; S. Yanai; M. Domukai; D. Toki; T. Hayashi; S. Kiuchi; H. Yasue; H. Uenishi; E. Kobayashi; T. Awata

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
308 KB
Volume
34
Category
Article
ISSN
0268-9146

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โœฆ Synopsis

Summary

Comparative mapping studies facilitate the identification of genes located in quantitative trait locus (QTL) regions in domestic animals by utilizing information from the human genome. Radiation hybrid (RH) mapping is effective for this purpose because of its high resolution in ordered gene mapping on chromosomes. We constructed an RH map of pig chromosome 7, by adding 23 markers associated with genes. This RH map clearly demonstrated the mosaic of homology between pig chromosome 7 (SSC7) and human chromosomes 6, 14 and 15 at a โ€˜geneโ€™ level, and was confirmed by linkage analysis. Clarification of the homology of SSC7 to human chromosomes will contribute to the elucidation of the gene(s) responsible for QTL detected on this chromosome.

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โœ X.-W. Shi; C. J. Fitzsimmons; C. Genรชt; R. Prather; K. Whitworth; J. A. Gr ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 133 KB

A comparative study of human chromosome 17 (HSA17) and pig chromosome 12 (SSC12) was conducted using both somatic cell hybrid panel (SCHP) and radiation hybrid (RH) panel analysis. Sequences from an expressed sequence tag (EST) project in pig reproduction were examined and six genes and ESTs origina