✦ LIBER ✦

Myelopoiesis in immunologically classified subgroups of childhood acute lymphocytic leukemia

✍ Scribed by Crist, William M. ;Ragab, Abdelsalem H. ;Vogler, Larry ;Lui, Victor K. S. ;Castleberry, Robert P. ;Findley, Harry W. ;Merijanian, Greg

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 405 KB
Volume: 8
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950080311

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Soft agar culture studies of 43 immunologically characterized patients with childhood acute lymphocytic leukemia (ALL) are presented. The immunologic subsets studied include “null”‐cell, pre‐B‐cell, and T‐cell leukemias. Abnormal myelopoiesis, including high peripheral blood and low marrow, colony‐forming cell numbers, low colony‐stimulating activity, and normal maturation of colony‐forming cells in vitro was noted in each group as previously described for immunologically uncharacterized ALL. We conclude that immunologic subsets of childhood lymphoblastic leukemia cause similar abnormalities of myelopoiesis. Lack of differences in growth characteristics among immunologic subsets of ALL make it impossible to use this tissue culture technique in sub‐classification of these leukemic disorders.

📜 SIMILAR VOLUMES

Immunologic classification of childhood

Immunologic classification of childhood acute lymphocytic leukemia

✍ Kenneth A. Foon; Philip Herzog; Ronald J. Billing; Paul I. Terasaki; Stephen A. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 424 KB 👁 3 views

Prospective study of childhood acute lym

Prospective study of childhood acute lymphocytic leukemia: Hematologic, immunologic, and cytogenetic correlations

✍ Michael, P. M. ;Carson, O. M. ;Ekert, H. ;Tauro, G. ;Rennie, G. C. ;Pilkington, 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 648 KB

We studied the karyotype in 81 consecutively diagnosed children with acute lymphocytic leukemia (ALL) treated at one institution on a randomized treatment protocol. In 75 patients (93%), a morphological cytogenetic result was obtained, and 57 (65%) were successfully G-banded. Of the 75 patients, 46

Hepatotoxicity of 6-mercaptopurine in ch

Hepatotoxicity of 6-mercaptopurine in childhood acute lymphocytic leukemia: Pharmacokinetic characteristics

✍ Berkovitch, Matitiahu; Matsui, Doreen; Zipursky, Alvin; Blanchette, Victor S.; V 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 423 KB 👁 2 views

From the Divisions of Clinical Pharmacology and Toxicology (M.B., D.M., G. K.

Spontaneous improvement of pneumocystis

Spontaneous improvement of pneumocystis carinii pneumonia in childhood acute lymphocytic leukemia

✍ Ettinger, Lawrence J. ;Torrisi, John ;Wood, Beverly P. ;Anderson, Virginia M. 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 938 KB

## Abstract Until recently, Pneumocystis carinii pneumonitis was the most common cause of death in patients with leukemia in remission. Prior to the advent of effective antimicrobial agents, this disease was virtually 100% fatal in the cancer patient undergoing immunosuppressive therapy. The sponta

The prognostic value of bone marrow lymp

The prognostic value of bone marrow lymphocytes in acute lymphocytic leukemia of childhood

✍ Alexander A. Green 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB 👁 3 views

Failure of early intensive chemotherapy

Failure of early intensive chemotherapy to improve prognosis in childhood acute lymphocytic leukemia

✍ Camitta, Bruce M. ;Pinkel, Donald ;Thatcher, L. G. ;Casper, James ;Kun, Larry E. 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 417 KB

## Abstract The ability of intensive therapy, early in remission, to improve prognosis in childhood acute lymphocytic leukemia was tested in a randomized study. The intensive treatment included cyclophosphamide (200 mg/m^2^ IV weekly × 4) and Adriamycin (40 mg/m^2^ IV weeks 1 and 3). These drugs we