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Hepatotoxicity of 6-mercaptopurine in childhood acute lymphocytic leukemia: Pharmacokinetic characteristics

✍ Scribed by Berkovitch, Matitiahu; Matsui, Doreen; Zipursky, Alvin; Blanchette, Victor S.; Verjee, Zul; Giesbrecht, Esther; Saunders, Earl F.; Evans, William E.; Koren, Gideon


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
423 KB
Volume
26
Category
Article
ISSN
0098-1532

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✦ Synopsis


From the Divisions of Clinical Pharmacology and Toxicology (M.B., D.M., G. K.


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A randomized study of methotrexate vs. 6-mercaptopurine and prednisone was carried out in 45 previously untreated patients with acute leukemia. Methotrexate was given orally in divided daily doses for 5-day courses a t intervals of ten to 14 days. Six-mercaptopurine and prednisone were given daily u