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Myeloid antigen positive acute lymphoblastic leukemia with the Philadelphia translocation and a jumping translocation of 1q in a child

✍ Scribed by Montgomery, K D; Winter, S S; Frost, J D; Hardekopf, D; Holt, K; Graham, M L; Foucar, K


Book ID
110055959
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
159 KB
Volume
18
Category
Article
ISSN
0887-6924

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Characterization of the translocation br
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We have previously described a patient in whom the breakpoint occurred within the first intron of the BCR gene and have cloned the 9q+ and 22q-junctions. We have now determined the nucleotide sequence around the breakpoints on both translocation products from this patient as well as the correspondin

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An 8 2 I translocation is a common chromosome abnormality associated with acute myeloblastic leukemia with maturation (M2 of French-American-British (FAB) classification). W e have isolated chromosome 2 I Nod linking clones; pulsed field gel electrophoresis analysis with one clone (LL263) detected a

Unusual expression of mRNA typical of Ph
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The Philadelphia chromosome (Ph) is found in both chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). The Ph translocation, t(9;22)(q34;qll), can disrupt the BCR gene on chromosome 22 in one to two areas called the major (Mbcrl) and minor (mbcrl) breakpoint cluster regions. In CML