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Molecular assignment of a translocation breakpoint in acute myeloid leukemia with t(8;21)

✍ Scribed by Dr. Kimiko Shimizu; Hitoshi Ichikawa; Hiroyuki Miyoshi; Misao Ohki; Hirofumi Kobayashi; Nobuo Maseki; Yasuhiko Kaneko

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 639 KB
Volume: 3
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870030302

No coin nor oath required. For personal study only.

✦ Synopsis

An 8 2 I translocation is a common chromosome abnormality associated with acute myeloblastic leukemia with maturation (M2 of French-American-British (FAB) classification). W e have isolated chromosome 2 I Nod linking clones; pulsed field gel electrophoresis analysis with one clone (LL263) detected an altered fragment of Nod-digested leukemic cell D N A carrying t(8;21). The altered fragment was shown to be produced by the 8;21 translocation. The breakpoint in chromosome 21 was located about I 3 kb to I00 kb proximal to the LL263 Nod site. Because the LL263 clone has a CpG island and is a short distance from the breakpoint, the clone itself may be considered as a candidate for part of the t(82 I ) associated gene.

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