Myelin Proteolipid Protein Gene Expression in Jimpy and Jimpymsd Mice
β Scribed by ; V. Gardinier; Wendy B. Macklin
- Book ID
- 111174536
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 1014 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-3042
No coin nor oath required. For personal study only.
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To identify putative sequences that direct cell type-specific expression and/or enhance proteolipid protein (PLP) gene expression, glial or nonglial cells were transfected with various PLP-luciferase constructs that collectively span the entire mouse PLP-specific DNA present in a transgene known to
The myelin proteolipid protein (Plp) gene is expressed in oligodendrocytes and encodes the most abundant protein (approximately 50%) present in mature myelin from the central nervous system (CNS). Plp gene activity is low to nonexistent early in development but sharply increases, concurrently with t