In 5-10% of all patients with typical generalised myasthenia gravis (MG), serum antibody to the acetylcholine receptor (AChR) is undetectable. To determine whether these represent a distinct subgroup, we have compared the thymuses of 14 seronegatives, 70 seropositives and 12 non-myasthenic controls.
Myasthenia gravis and the thymus gland. A historical review
β Scribed by Marius Raica; Anca Maria Cimpean; Domenico Ribatti
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 41 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0372-8722
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In both normal and neoplastic epithelial cells from human thymus glands and thymomas, respectively, we found voltage-gated sodium and potassium channels that resemble the adult-type Na channel and the delayed outward rectifier K channel, respectively, of human skeletal muscle and mammalian nervous s
## Abstract Previous studies have described an experimental model of myasthenia gravis (MG) produced by immunizing animals with thymus extracts. In view of the hypothesis that the autoimmune process in MG may be initiated within the thymus itself, we have reexamined this model using presently avail