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Mutator phenotype due to loss of heterozygosity in diploid yeast strains with mutations in MSH2 and MLH1

✍ Scribed by Karin Drotschmann; Polina V Shcherbakova; Thomas A Kunkel


Book ID
119540952
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
154 KB
Volume
112-113
Category
Article
ISSN
0378-4274

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Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred