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Mutations within the CD81-binding sites and hypervariable region (HVR) 2 of the envelope (E) 2 protein and correlation with treatment response in HCV infected patients

✍ Scribed by W.Peter Hofmann; Christoph Sarrazin; Bernd Kronenberger; Katharina Bruch; Barbara Schonberger; Stefan Zeuzem


Book ID
118564987
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
168 KB
Volume
36
Category
Article
ISSN
0168-8278

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## Abstract Heterogeneity of subgenomic regions of hepatitis C virus (HCV) may be associated with response to interferon (IFN) therapy. The amino acid sequences of the PKR/eIF‐2Ξ± phosphorylation homology domain (pePHD), IFN sensitivity determining region (ISDR), PKR binding domain (PKRBD), and vari