## Abstract The incidence and pattern of mutations of the __ras__ oncogenes and the __p53__ tumor suppressor gene have been shown to differ among different cancer types and even among the same cancer types with different etiological backgrounds. For example, in a previous study we showed that not o
Mutations of p53 Tumor Suppressor Gene, Apoptosis, and Proliferation in Intrahepatic Cholangiocellular Carcinoma of the Liver
✍ Scribed by Andrea Tannapfel; Lars Weinans; Felix Geißler; Alexander Schũtz; Alexander Katalinic; Ferdinand Kõckerling; Johann Hauss; Christian Wittekind
- Book ID
- 110224558
- Publisher
- Springer US
- Year
- 2000
- Tongue
- English
- Weight
- 342 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0163-2116
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Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We ana
## Abstract Immunohistochemical, immunoblotting, and DNA‐sequencing analyses were performed on hepatocellular carcinomas induced in rats chronically fed BR931, a peroxisome proliferator, to determine whether the tumors carried mutations or other alterations of the __p53__ gene. None were detected.