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Lack of mutations of the p53 tumor suppressor gene in hepatocellular carcinomas induced in rats by a peroxisome proliferator

✍ Scribed by Martin L. Smith; Lakshmi Yeleswarapu; Benito Lombardi; Hisashi Shinozuka

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
521 KB
Volume
7
Category
Article
ISSN
0899-1987

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✦ Synopsis

Abstract

Immunohistochemical, immunoblotting, and DNA‐sequencing analyses were performed on hepatocellular carcinomas induced in rats chronically fed BR931, a peroxisome proliferator, to determine whether the tumors carried mutations or other alterations of the p53 gene. None were detected. Inactivation of this tumor suppressor gene does not appear, therefore, to be involved in the carcinogenicity of BR931, a nongenotoxic chemical hepatocarcinogen.

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