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Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

โœ Scribed by Macchi, Paolo; Villa, Anna; Giliani, Silvia; Sacco, Maria G.; Frattini, Annalisa; Porta, Fulvio; Ugazio, Alberto G.; Johnston, James A.; Candotti, Fabio; O'Sheai, John J.


Book ID
109793886
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
865 KB
Volume
377
Category
Article
ISSN
0028-0836

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Mutations in severe combined immune defi
โœ Luigi D. Notarangelo; Patrizia Mella; Alison Jones; Genevieve de Saint Basile; G ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 407 KB

During the last 10 years, an increasing number of genes have been identified whose abnormalities account for primary immunodeficiencies, with defects in development and/or function of the immune system. Among them is the JAK3-gene, encoding for a tyrosine kinase that is functionally coupled to cytok