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Mutations of IDH1 and IDH2 are not detected in brain metastases of colorectal cancer

โœ Scribed by Matthias Holdhoff; D. Williams Parsons; Luis A. Diaz

Publisher
Springer US
Year
2009
Tongue
English
Weight
95 KB
Volume
94
Category
Article
ISSN
0167-594X

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## Abstract Missense somatic mutations in __IDH1__ gene affecting codon 132 have recently been reported in glioblastoma multiforme (GBM) and other gliomas. The recurrent nature of the __IDH1__ mutations in the same amino acid strongly suggests that the mutations may play important roles in the path