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IDH1 and IDH2 hotspot mutations are not found in canine glioma

✍ Scribed by Zachary J. Reitman; Natasha J. Olby; Christopher L. Mariani; Rachael Thomas; Matthew Breen; Darell D. Bigner; Roger E. McLendon; Hai Yan

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
101 KB
Volume
127
Category
Article
ISSN
0020-7136

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✦ Synopsis

With great interest, we read the recent publication ''CD44positive cells are responsible for gemcitabine resistance in pancreatic cancer cells'' by Hong et al. 1 In this study, the authors established gemcitabine-resistant pancreatic cancer cells in vitro and characterized them in various ways, in vitro and in vivo. The authors describe these gemcitabineresistant cells as being more tumorigenic in vitro and in vivo as judged from colony formation assays and tumor

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IDH1 mutations at residue p.R132 (IDH1R1
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Systematic sequence profiling of the Glioblastoma Multiforme (GBM) genome has recently led to the identification of somatic mutations in the isocitrate dehydrogenase 1 (IDH1) gene. Interestingly, only the evolutionarily conserved residue R132 located in the substrate binding site of IDH1 was found m