## Abstract Germline mutations in __CHEK2__ have been associated with a range of cancer types but little is known about disease risks conveyed by __CHEK2__ mutations outside of the context of breast and prostate cancer. To investigate whether __CHEK2__ mutations confer an increased risk of bladder
Germline mutations of AXIN2 are not associated with nonsyndromic colorectal cancer
โ Scribed by Paolo Peterlongo; Louise R. Howe; Paolo Radice; Paola Sala; Young-Joon Hong; Seok-Il Hong; Nandita Mitra; Kenneth Offit; Nathan A. Ellis
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 96 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1059-7794
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## Abstract Activating mutations of __BRAF__ have been frequently observed in microsatellite unstable (MSI^+^) colorectal carcinomas (CRCs), in which mutations of __BRAF__ and __KRAS__ are mutually exclusive. Previously, we reported that hypermethylation of __hMLH1__ might play an important role in