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Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors

✍ Scribed by Moskaluk, C A; Tian, Q; Marshall, C R; Rumpel, C A; Franquemont, D W; Jr, HF Frierson


Book ID
110061944
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
522 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract Gastrointestinal stromal tumors are mesenchymal tumors arising in the stomach and small bowel and more rarely in the rectum, esophagus, peritoneum and retroperitoneum. These tumors are characterized by __KIT__ or __PDGFRA__ mutations. __KIT__ mutations are all in frame and lead to const