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Mutations in the von Hippel-Lindau (VHL) gene refine differential diagnostic criteria in renal cell carcinoma

โœ Scribed by Nandita Barnabas; Mitual B. Amin; Kirit Pindolia; Reshma Nanavati; Mahul B. Amin; Maria J. Worsham

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
234 KB
Volume
80
Category
Article
ISSN
0022-4790

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## Communicated by Lap-Chee Tsui Von Hippel-Lindau (VHL) disease is a dominantly inherited disorder predisposing those afflicted to hemangioblastomas of the central nervous system and the retina, renal cell carcinomas, pheochromocytomas, and pancreatic tumors. The disease has been associated with

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## Abstract It has been documented that renal cell carcinomas (RCCs) occur frequently in patients treated with longโ€term dialysis, especially in cases of endโ€stage renal disease (ESRD)/acquired cystic disease of the kidney (ACDK). To address the molecular pathogenesis of ESRD/ACDKโ€associated RCCs,