Mutations in the NS5A and E2-PePHD regions of hepatitis C virus genotype 1b and response to combination therapy of interferon plus ribavirin
β Scribed by Sheng-Shun Yang; Ming-Yang Lai; Ding-Shinn Chen; Gran-Hum Chen; Jia-Horng Kao
- Book ID
- 111237203
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 132 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0106-9543
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A part of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) amino acid sequence, designated as an interferon (IFN)-sensitive determining region (ISDR), has been shown to be correlated with a response to IFN in Japanese patients. We have shown previously that the presence of NS5A antibodies
## Abstract Hepatitis C virus (HCV) genotype 1a is rare in Japanese patients and the clinical characteristics of this genotype remain unclear. The interferon (IFN) sensitivityβdetermining region (ISDR) and singleβnucleotide polymorphisms (SNPs) of interleukinβ28B (IL28B) among patients with HCV gen