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Association of interleukin 28B and mutations in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy

✍ Scribed by Kazuhiko Hayashi; Yoshiaki Katano; Takashi Honda; Masatoshi Ishigami; Akihiro Itoh; Yoshiki Hirooka; Tetsuya Ishikawa; Isao Nakano; Kentaro Yoshioka; Hidenori Toyoda; Takashi Kumada; Hidemi Goto


Book ID
111239580
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
151 KB
Volume
31
Category
Article
ISSN
0106-9543

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Prevalence of hepatitis C virus genotype
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## Abstract Hepatitis C virus (HCV) genotype 1a is rare in Japanese patients and the clinical characteristics of this genotype remain unclear. The interferon (IFN) sensitivity‐determining region (ISDR) and single‐nucleotide polymorphisms (SNPs) of interleukin‐28B (IL28B) among patients with HCV gen

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A part of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) amino acid sequence, designated as an interferon (IFN)-sensitive determining region (ISDR), has been shown to be correlated with a response to IFN in Japanese patients. We have shown previously that the presence of NS5A antibodies