Association of interleukin 28B and mutations in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy
β Scribed by Kazuhiko Hayashi; Yoshiaki Katano; Takashi Honda; Masatoshi Ishigami; Akihiro Itoh; Yoshiki Hirooka; Tetsuya Ishikawa; Isao Nakano; Kentaro Yoshioka; Hidenori Toyoda; Takashi Kumada; Hidemi Goto
- Book ID
- 111239580
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 151 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0106-9543
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## Abstract Hepatitis C virus (HCV) genotype 1a is rare in Japanese patients and the clinical characteristics of this genotype remain unclear. The interferon (IFN) sensitivityβdetermining region (ISDR) and singleβnucleotide polymorphisms (SNPs) of interleukinβ28B (IL28B) among patients with HCV gen
A part of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) amino acid sequence, designated as an interferon (IFN)-sensitive determining region (ISDR), has been shown to be correlated with a response to IFN in Japanese patients. We have shown previously that the presence of NS5A antibodies