Mutations in the Basal Core Promoter and Precore/Core Gene of Hepatitis B Virus in Patients with Chronic Active but not Acute Hepatitis B
β Scribed by C. Mayerat; A. Mantegani; F. Spertini; P. C. Frei
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 158 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0934-9723
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## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in
The core promoter region of hepatitis B virus genomes regulates transcription of the precore and pregenomic mRNAs encoding hepatitis B e antigen (HBeAg) and core antigen that contain target epitopes for cytotoxic T lymphocytes. The prevalence and clinical significance of mutations in this region wer
and who developed recurrent HBV infection were evaluated for the study. Patients infected Abbreviations: HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; nt, nucleowith hepatitis C or delta virus were excluded, leaving a study group tide; HBeAg, hepatitis B e antigen; PCR, polymerase chai
## Abstract The A1762T and G1764A mutations in the basal core promoter (BCP) region and the G1896A mutation in the precore (PC) region of hepatitis B virus (HBV) genome are found commonly in HBeAgβnegative patients. Experiments in vitro suggest that BCP and PC mutation reduce and abolish HBeAg expr