Hepatitis B virus: mutations in the precore/basal core promoter and viral replication
β Scribed by Akinori Rokuhara; Kendo Kiyosawa
- Publisher
- Springer Japan
- Year
- 2002
- Tongue
- English
- Weight
- 40 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0944-1174
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The precore-core gene of hepatitis B virus (HBV) was directly sequenced from serum samples of 42 patients with chronic B hepatitis (19 hepatitis B e antigen [HBeAg]+ and 23 anti-me+). Viral genotypes were determined by comparison with ll reference sequences and by restriction analysis. Genotype A wa
## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in
In spite of hepatitis B virus (HBV) vaccination, HBV infection remains an important public health problem worldwide. Although the HBV genotype distribution has been determined in some parts of South Central Asia, no survey has been conducted to determine the HBV genotype in Afghanistan. Twelve Afgha
## Abstract The evolution of precore stop codon mutation (A1896) and dinucleotide mutation (T1762/A1764) in the basic core promoter (BCP) of hepatitis B virus (HBV) genome during transient seroconversion and seroreversion of hepatitis B e antigen (HBeAg) remains unclarified. Five HBeAgβpositive HBV