Hepatitis B virus (HBV) is characterized by genetic heterogeneity, including genotypes and mutations. Eight genotypes (A-H) have been identified throughout the world with a characteristic geographical distribution. Previous studies also suggest that the viral genotypes may correlate with differences
Hepatitis B genotypes and precore/basal core promoter mutants in HBeAg-negative chronic hepatitis B
β Scribed by Chih-Lin Lin; Li-Ying Liao; Chun-Jen Liu; Pei-Jer Chen; Ming-Yang Lai; Jia-Horng Kao; Ding-Shinn Chen
- Publisher
- Springer Japan
- Year
- 2002
- Tongue
- English
- Weight
- 61 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0944-1174
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## Abstract The association of precore stop codon mutation (A1896), dinucleotide mutation (T1762/A1764) in the basic core promoter of hepatitis B virus (HBV) genome, and genotype of HBV with fulminant or subfulminant hepatitis remains controversial. We studied HBV genotypes as well as mutations in
## Abstract The A1762T and G1764A mutations in the basal core promoter (BCP) region and the G1896A mutation in the precore (PC) region of hepatitis B virus (HBV) genome are found commonly in HBeAgβnegative patients. Experiments in vitro suggest that BCP and PC mutation reduce and abolish HBeAg expr
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