Oral squamous-cell carcinoma (SCC) is the most common neoplasm in Sri Lanka, accounting for approximately 30% of all cancers in males. Epidemiologic evidence indicates that there is an unequivocal relationship between betel chewing and oral carcinogenesis, suggesting that there may be specific genet
Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers
โ Scribed by Peter A. Heinzel; Prabha Balaram; Hans-Ulrich Bernard
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 439 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
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Previous studies of oral cancer have suggested that alterations of the p53 tumour suppressor gene occur early in the precancerous stage of development. However, these observations have been based on cross-sectional assessment of abnormal p53 protein staining by immunohistochemistry and may not neces
In Table I of the above-noted article, the column head ''Betel-liquid'' should have been ''betel-quid''. The corrected Table is reprinted here.
## Detection of mutations and polymorphisms in the p53 tumor suppressor gene by single-strand conformation polymorphism analysis Deciphering the genetic mechanisms in cancer development requires analysis of a large number of tumors for consistent genetic alterations. Single-strand conformational p
There have been few reports on genetic alterations in thymomas. To investigate the expression of p16 INK4A , RB, p53 and cyclin D1 in thymomas, we first examined 36 thymomas (non-invasive type, 16 cases; invasive type, 20 cases) and 3 thymic carcinomas, using immunohistochemistry. Abnormal expressio