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Mutational status of FGFR3 in oral squamous cell carcinoma

Book ID
119335900
Publisher
Elsevier
Year
2012
Tongue
English
Weight
117 KB
Volume
114
Category
Article
ISSN
2212-4403

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Constitutive activating mutation of the
Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas
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A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells